diagnosis and management of multiple sclerosis in children

how to cite this article: najafi mr, najafi ma, nasr z. diagnosis and management of multiple sclerosis in children. iran j child neurol. summer 2016; 10(3): 13-23. abstract growing evidence indicates the safety and well toleration of treatment by disease-modifying in children suffering multiple sclerosis (ms). the treatment is not straight forward in a great number of patients, thus patients with pediatric ms must be managed by experienced specialized centers. common treatments of multiple sclerosis for adults are first-line therapies. these therapies (firstline) are safe for children. failure in treatment that leads to therapy alteration is almost prevalent in pediatric ms. toleration against current second-line therapies has been shown in multiple sclerosis children. oral agents have not been assessed in children ms patients. although clinical trials in children are insufficient, immunomodulating managed children, experience a side effect similar to the adult ms patients. however, 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